Down-Regulation of IFN- –Producing CD56 T Cells after Combined Low-Dose Cyclosporine/Prednisone Treatment in Patients with Behçet’s Uveitis
نویسندگان
چکیده
METHODS. Ten patients with Behçet’s uveitis and 10 healthy control subjects were prospectively recruited. The patients were treated with Cs/Pd for 2 months. Phenotypic and functional changes in circulating CD56 T cells were assayed before and after treatment. CD56 T-cell subsets were determined by flow cytometric analysis with monoclonal antibodies for CD3, CD4, CD8, CD56, pan TCR, and V 24. The absolute numbers of cells in the lymphocyte subsets were calculated. Cytokine (IFN, IL-4, and IL-10) expressions were measured by ELISA and by intracellular cytokine staining.
منابع مشابه
Down-regulation of IFN-gamma-producing CD56+ T cells after combined low-dose cyclosporine/prednisone treatment in patients with Behçet's uveitis.
PURPOSE To investigate the effects of combined low-dose cyclosporine and prednisone (Cs/Pd) treatment on circulating CD56+ T cells in patients with Behçet's uveitis. METHODS Ten patients with Behçet's uveitis and 10 healthy control subjects were prospectively recruited. The patients were treated with Cs/Pd for 2 months. Phenotypic and functional changes in circulating CD56+ T cells were assay...
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